毋问我从哪里来 发表于 2021-9-10 21:56
◆样品检验情况：中检院按照中心核定的质量标准，对产品（规格20mg）和产品（规格50mg）进行检验，均符合 ...
针对上述工艺验证问题，经技术会审讨论认为：现场检查后企业按要求分别对两规格制剂重新进行了工艺验证。工艺验证批20mg规格所用原料药批号（保密）；50mg规格所用原料药批号（保密）。其中（保密）两批所用中间体FG-6347为两步结晶，与核定的/申报的工艺一致，其余四批原料药所用中间体FG-6347均为一步结晶，与核定的/申报的工艺不一致。鉴于企业重新工艺验证中仅有两批制剂对应原料药所用中间体FG-6347为两步结晶，建议药审中心在三合一审评时予以关注。现场检查结论为“通过”。后来，2018年11月23日CDE召开了药学专业会议讨论认为，基于现有数据，本品从技术上分析风险可控，可以接受。
毋问我从哪里来 发表于 2021-9-10 21:56
针对上述工艺验证问题，经技术会审讨论认为：现场检查后企业按要求分别对两规格制剂重新进行了工艺验证。 ...
◆核查中心于2018年6月22日-28日组织核查组，按照《药物临床试验数据现场核查要点》（国家食品药品监督管理总局公告2015年第228号）内容对该品种申报的药物临床试验数据开展了现场核查。2018年7月9日-10日，核查中心召开了药物临床试验数据核查评审会，听取了核查组对现场核查情况的汇报，并对发现问题和注册申请单位与被检查单位提交的问题说明进行了审评。2018年7月12日核查中心召开了沟通会，就现场核查和会审情况同注册申请单位进行了沟通，注册申请单位对专家会审核结论无异议。
毋问我从哪里来 发表于 2021-9-10 21:56
◆核查中心于2018年6月22日-28日组织核查组，按照《药物临床试验数据现场核查要点》（国家食品药品监督管 ...
被核查单位包括上海交通大学医学院附属瑞金医院、上海交通大学医学院附属新华医院、南京医科大学第一附属医院、东南大学附属中大医院、科文斯医药研发（上海）有限公司。经核查未发现该临床试验存在真实性问题，主要为规范性问题：受试者筛选/入组；临床试验数据溯源；方案违背；安全性记录、报告；试验用药品管理与记录；生物样本运输、交接、保存方面的问题。核查发现4个研究中心均有多例AE漏报，部分是由于研究者疏忽所致，部分是研究者结合受试者既往病史、原发病特点、临床症状、体征等情况对实验室检查异常值判定为NCS而未报AE的情况。漏报AE中未出现新的非预期或临床不可控的安全性问题。现有不合格项目对本品的有效性和安全性评价结果没有重大影响，不改变临床对本品获益/风险的判读结论。
毋问我从哪里来 发表于 2021-9-10 21:56
被核查单位包括上海交通大学医学院附属瑞金医院、上海交通大学医学院附属新华医院、南京医科大学第一附属 ...
第三部分：FDA拒绝批准2021年8月11日，FibroGen公司官网发布《FibroGen Receives Complete Response Letter from the FDA for Roxadustat for Anemia of Chronic Kidney Disease》。其中提到：The letter indicates the FDA will not approve the roxadustat NDA in its present form and has requested additional clinical study of roxadustat be conducted, prior to resubmission. 这意味着如果FibroGen公司想再次提出重新申请，需要按照FDA要求补充新的临床试验数据。（参见下面截图）
https://med.sina.com/files/20210823/png/1629688714874.png
毋问我从哪里来 发表于 2021-9-10 21:56
第三部分：FDA拒绝批准2021年8月11日，FibroGen公司官网发布《FibroGen Receives Complete Response Lett ...
在美国FDA官网查询到2021年7月15日发布的《FDA Briefing Document- Roxadustat》和《Roxadustat for the Treatment of Anemia Due to Chronic Kidney Disease in Adult Patients not on Dialysis and on Dialysis》都对罗沙司他产品的安全性提出了质疑：
https://med.sina.com/files/20210823/png/1629688723680.png
毋问我从哪里来 发表于 2021-9-10 21:57
在美国FDA官网查询到2021年7月15日发布的《FDA Briefing Document- Roxadustat》和《Roxadustat for the...
根据上面文件截图可以看出，在心血管安全方面，罗沙司他在透析依赖型（DD）患者中与epoetin-alfa的相比而言风险更高；而在非透析依赖性（NDD）患者中与安慰剂的相比而言，风险更高。和FDA文件信息相对应的是，在2021年4月6日，FibroGen首席执行官表示：“当高级管理层成员正在为即将举行的FDA咨询委员会会议做准备时，我们意识到，主要心血管安全分析包括对分层因素的临时调整。虽然以下所有分析，包括分层因素的差异，都包含在NDA申报资料中，但公司迅速决定与FDA澄清这个问题，并与科学界和投资界沟通。“同时表示，FibroGen公司已开始进行全面的内部审查，以确保今后不会发生此类问题。
毋问我从哪里来 发表于 2021-9-10 21:57
根据上面文件截图可以看出，在心血管安全方面，罗沙司他在透析依赖型（DD）患者中与epoetin-alfa的相比而 ...
第四部分：其他地区注册进展根据目前掌握的信息，罗沙司他除了在中国获得批准上市以外，罗沙司他已在日本、智利、韩国获批用于治疗透析（DD）及非透析（NDD）成人患者的CKD贫血。2019年9月20日，罗沙司他在日本获批上市，用于治疗透析慢性肾病患者的贫血，商品名为Evrenzo；2020年12月，日本厚生劳动省（MHLW）批准Evrenzo（中文商品名：爱瑞卓，通用名：roxadustat，罗沙司他），用于非透析依赖（NDD）。
毋问我从哪里来 发表于 2021-9-10 21:57
第四部分：其他地区注册进展根据目前掌握的信息，罗沙司他除了在中国获得批准上市以外，罗沙司他已在日本 ...
第五部分：EC批准罗沙司他，行业持续高度关注当地时间2021年8月19日，对于FibroGen公司注定是不同寻常的。因为EC批准了罗沙司他，FibroGen公司官网高调宣布此消息，以提振市场信心。在欧盟市场，安斯泰来负责罗沙司他产品的注册和推广，商品名是Evrenzo。在2021年6月24日发布的《Summary of opinion-initial authorisation》中，EMA表达了自己的积极观点：On 24 June 2021, the Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion, recommending the granting of a marketing authorisation for the medicinal product Evrenzo, intended for the treatment of anaemia symptoms in patients with chronic kidney disease。这个好消息的到来，应该会让珐博进公司和安斯泰来公司的管理层有个好心情。
毋问我从哪里来 发表于 2021-9-10 21:57
第五部分：EC批准罗沙司他，行业持续高度关注当地时间2021年8月19日，对于FibroGen公司注定是不同寻常的 ...
总结虽然随着EC批准罗沙司他在欧盟市场上市，让珐博进公司和与其合作的业务伙伴暂时松了一口气，并坚定了自己的信心。但是鉴于美国FDA在国际医药市场的权威地位，以及FDA在审评文件中提出的安全性问题和数据规范管理的问题，相信罗沙司他这个产品在以后的使用中，会被各地药政官方所关注并加强监管；而作为MAH的各方主体，更应该积极履行法律责任，积极开展上市后的安全研究，用扎实的上市后真实世界证据来补充临床研究中的不足。至于罗沙司他在美国市场的命运，目前还需要持谨慎观望态度。参考资料：1-FibroGen官网2-中国CDE罗沙司他胶囊申请上市技术审评报告3-EMA官网审评信息4-FDA官网信息
东北制药将被全面要约收购
来源： 新浪医药新闻 2021-08-23
8月23日，东北制药发布公告称，方大钢铁受让东药集团、盛京金控集团持有的东北制药全部股份而触发要约收购。data:image/png;base64,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本次转让完成后，方大钢铁及其一致行动人合计持有公司57.88%股份。方大钢铁向东北制药除方大钢铁及其一致行动人、东药集团、盛京金控集团以外的其他股东发出全面要约收购，要约收购价格为4.93元/股。本次要约收购不以终止东北制药上市地位为目的。据悉，东药集团、盛京金控集团于6月在沈阳联合产权交易所公开征集其持有的东北制药全部股份受让方，转让股份为2.55亿股，占东北制药总股本的18.91%。7月3日，方大钢铁成为股份最终受让方，并于7月4日与东药集团、盛京金控集团签署了股份转让协议。本次转让前，方大钢铁及其一致行动人已合计持有东北制药5.25亿股股份，占公司股份总数的38.97%，持股比例超过30%。本次转让完成后，方大钢铁及其一致行动人合计持有东北制药7.8亿股股份，占公司股份总数的57.88%。
2021药品带量采购半程梳理
来源： 医药魔方 2021-09-02
作者 | 山东风轻2015年是分类采购真正尝试推进的一年。2016年是医疗机构充分发挥采购主体的一年。2017年是以医保支付为基础阳光挂网落地的一年，2018年是开始发挥医保主导药品采购作用的一年，2019年是国家药品集中采购探索创新的关键一年，2020则是药品集中采购制度逐渐落地的一年，回顾过去的五年，带量采购从悬在空中有价无量，直到现在的落地生根、量价结合，可以说，药品集中采购的步伐正步履稳健，越走越实。2021年，回顾过去的8个月，再展望接下来的日子，带量采购无疑正由点及面、全面铺开。集定价权、采购权、支付权于一身的医保持续发力，以集采为抓手，小切口，深突破，带量采购正从原来的十字路口坚定走向深水区，开始调整采购结构，并向重点品种、重点范围开始发力运行。
毋问我从哪里来 发表于 2021-9-10 22:00
2021药品带量采购半程梳理
来源： 医药魔方 2021-09-02
采购目录：500品种仍具有带量采购指导性2020年的500目录至今，仍然作为国家及各省带量采购的基础。包括马上开始的湖北中成药专项采购以及广东省际带量采购联盟，品种的选择基本上无出其右。目前省级带量采购的基本定调就是，年度任务为50个以内（包括省际、本省、省级市际联合），目前来看，甚至不排除一些国采续约品种可以计算在内（上海、广东等省）。笔者再次强调：500个品种并非固定存在没有变化的。2021年的相关中心点，会以500个品种为中心，快速扩散，直接辐射到目前临床在用的全部品种。这2020年流传的500个品种，相信只是统计到相应时间段的一个相对固态的范围。而到了2021、2022年，随着国家带量采购、过评进度等因素导致临床用药发生的相关变化，500个品种预计会有进有出。500目录 “怎么进、怎么出、什么时候进、什么时候出、怎样用时间换空间”等具体步骤都需要企业慎重决策。
毋问我从哪里来 发表于 2021-9-10 22:00
采购目录：500品种仍具有带量采购指导性2020年的500目录至今，仍然作为国家及各省带量采购的基础。包括马 ...
品种选择：重点领域用药无缝打击进入带量采购品种层面，全身用抗感染药、消化系统及新陈代谢用药、心血管用药、神经系统及抗肿瘤用药成为国家及地方采购重点。随着大品种陆续被国采、省采纳入，剩余的成熟品种最多也就是两至三年将会被带量采购完毕。另外，生物类似药、中成药等带量采购规则会更为优化、更有针对性、质量更符合药本身的属性。今年四季度，湖北中成药专项采购、广东省际带量采购联盟、国家胰岛素专项采购，这三个项目基本上就能够提示生物类似药与中成药下一步的走向。相关品种进入带量采购，对企业的要求是，从品种选择布局层面，要从以前的大而广转向精而专，要集中精力做好关键品种，从原料等各项成本方面、药物警戒体系等质量管理方面进行管控。
毋问我从哪里来 发表于 2021-9-10 22:00
品种选择：重点领域用药无缝打击进入带量采购品种层面，全身用抗感染药、消化系统及新陈代谢用药、心血管 ...
采购方式：分类采购扎实落地，价格扭转唯低价是取可以看到，原来地方开展的药品集中采购试点，尤其是以市一级的带量采购试点，将越来越聚焦归拢到省级层面。市级层面单独再开展带量采购的可能性将越来越小。今年，通过河南豫中联盟、先前传出后来生变的山东新一轮带量采购等项目可以看到，省级集采部门将统筹规划部署全省带量采购工作。一分为二来看，省级层面能够开展集采的品种，由省级组织。省级层面暂不方便开展集采的品种，将在省级组织方的指导下，授权至少三个以上地级市开展集采。各省级带量采购包括各医联体（医疗机构）的采购参与度将继续强化，分类采购的思路仍将沿续。对于用量大药企众多的产品，各省将以国家联采、湖北武汉集团采购为蓝本进行集团采购，用量少及部分独家、专利药品将开展议价确标或谈判。同时，备案采购、撮合交易、询价采购将呈现常态步骤。
毋问我从哪里来 发表于 2021-9-10 22:00
采购方式：分类采购扎实落地，价格扭转唯低价是取可以看到，原来地方开展的药品集中采购试点，尤其是以市 ...
值得注意的是，在临床路径与按病种付费的背景下，医疗一线资源利用控制将更加严格，将讲究疗效确切的同时医院将主动参与成本控制。从历年的国家带量采购及省级项目可以看出，药品集采组织方的思路正在逐渐从唯低价是取到合理价格下保障供应的转变，尤其是在化药价格带量采购到一定程度之后，集采组织方大概率不会在此基础上再次大幅杀价，取而代之的是价格联动、入围续约、价格调整。这一点，通过上半年上海国采续约及部分国采品种有一定幅度的价格微微上调就可以看到集采方向的变化。
毋问我从哪里来 发表于 2021-9-10 22:01
值得注意的是，在临床路径与按病种付费的背景下，医疗一线资源利用控制将更加严格，将讲究疗效确切的同时 ...
写在最后：基药变局或搅动带量采购市场不出意外，2021年，国家基药调整将正式启动并公布结果，坊间传闻，下半年，国家基药目录将正式出台。而进入国家基药的中成药，基本上都是功能主治明确、临床报告完整、疗效切实安全、剂型服用方便的品种。动手对新版国家基药品种进行集中带量采购，无疑既是路线正确又是合情合理的事情。而目前了解到，基药全面扩容，已经是板上钉钉。作为一个政策性产品，既有目录带来的种种好处，也存在政策带来的种种风险。但无论如何，基药公布之日，作为带量采购的必须品种，基药无疑将给各省带量采购又提供了一种选择，毕竟，将国家基药品种开展一次带量采购，将助力把1+X有关政策执行到位。总之，新形势下，带量采购即准入！带量采购考验的是一个价格决策能力，更考验的是一个企业战略决策能力，即：对仿制药一致性评价认知能力+企业对仿制药一致性发展方向决策能力+产品筛选决策能力。以往的粗放式价格决策体系必须以市场先导为抓手，国家及地方开展带量采购，对企业来说，也要树立一个带量投标的意识：市场有多少存量，未来有多少增量，才是决定一个市场做与不做、投标与否的衡量标准。
八部门印发医疗价格改革方案将这样影响药企
来源： 赛柏蓝 作者： 徐毓才 2021-09-02
医疗服务价格改革试点方案公布，对于医药企业有何影响？8月31日， 国家医保局等八部门联合印发 《深化医疗服务价格改革试点方案》的通知（医保发〔2021〕41号，以下简称《方案》）。《方案》是2018年国家医保局组建统筹推动三医联动改革以来就医疗服务价格改革印发的第一份文件，也是5月21日中央全面深化改革委员会第十九次会议审议通过后《方案》的正式公布。
毋问我从哪里来 发表于 2021-9-10 22:02
八部门印发医疗价格改革方案将这样影响药企
来源： 赛柏蓝 作者： 徐毓才 2021-09-02
https://med.sina.com/files/20210902/png/1630554872803.png
《方案》正如国家医保局成立以来每一次动作一样，都是“惊天动地”。医疗服务价格改革相对药品耗材集采和医保支付制度改革好像一直没啥动静，但一旦动起来就不同凡响。那么作为医药企业能够从《方案》看到什么？今天笔者就与大家梳理梳理。
毋问我从哪里来 发表于 2021-9-10 22:02
《方案》正如国家医保局成立以来每一次动作一样，都是“惊天动地”。医疗服务价格改革相对药品耗材集采 ...
01 医用耗材从价格项目中逐步分离大家都知道，我国医疗服务价格中，通常包括项目名称、计价单位、最高限价、项目内涵、除外内容和说明。为了便于项目收费方便和财务管理，每一个收费项目还有一个固定的编码和财务分类。而“项目内涵”中通常使用“含”、“包括”、“不含”三个专用名词来界定：“含”指该项目应当提供的服务内容，不得单独分解计费，比如胰岛素注射每次费用就“含”专用胰岛素注射器，鼻饲管置管每次费用就“含”鼻饲管；“包括”指与该项目不同的服务内容或技术方法，按该项目价格计价，比如持续吸氧每日费用中就“包括”一次性鼻导管和鼻塞等；“不含”指可另单独计价的内容，比如切痂术收费中“不含”植皮。当然“除外内容”自然都是可以另外计费的，大部分医疗器材都属于。比如持续吸氧每日费用中就“包括”一次性鼻导管和鼻塞等，但“一次性面罩”就是除外内容。
毋问我从哪里来 发表于 2021-9-10 22:03
01 医用耗材从价格项目中逐步分离大家都知道，我国医疗服务价格中，通常包括项目名称、计价单位、最高限 ...
这也就是说在医疗服务收费项目中总有一些医用耗材“含”或“包括”在收费项目内，不能单独收费，而还有一部分是“不含”在项目内或“除外内容”，可以单独收费。而这一次《方案》对收费项目管理的规定是：完善全国价格项目规范。在充分听取临床专家等意见基础上，分类整合现行价格项目，完善全国医疗服务价格项目规范，统一价格项目编码，逐步消除地区间差异。实现价格项目与操作步骤、诊疗部位等技术细节脱钩，增强现行价格项目对医疗技术和医疗活动改良创新的兼容性，合理压减项目数量。医用耗材从价格项目中逐步分离，发挥市场机制作用，实行集中采购、“零差率”销售。这也就是说今后医用耗材将逐步变为价格项目中的“不含”和“除外内容”，可以单独收费，实际上对于医药企业来讲是一点小小的“福利”，特别是过去那些“包括”及“含”在内的耗材和药品。